In CNS, enterohromaffinopodobnyh cells unimaginative gastric M1holinoretseptor, in the unimaginative - M2holinoretseptor, in smooth muscles Grain internal organs, glands and vascular endothelium - M3holinoretseptor (Table. By irritating Drugs include: ammonia, mustard essential oil, 20-40% ethyl alcohol, menthol, pepper patch, ointment «Finalgon» and other irritant, stimulating sensory receptors, can cause reflex responses. Acetylcholine is synthesized in the cytoplasm of cholinergic nerve endings from atsetilkoenzima A and choline, by active transport enters the vesicles and deposited in the vesicles. In addition, there are a group of substances that Prior to admission stimulate specific receptors. Axons of ganglion neurons (postganglionic sympathetic fibers) extend beyond the ganglia and end in cells innervated organs and tissues, forming neyroeffektornye synapses. In the ganglia of the end of these fibers (called preganglionic sympathetic fibers) contact with the nerve cells of ganglia (ganglion neurons) forming ganglion synapses. In connection with the stimulation of muscarine M2holinoretseptorov slowed heart beat (bradycardia causes) and hinders atrioventricular conduction. These synapses in the tradition called adrenergic (previously believed that the mediator in these is adrenalin). This is due to the fact that the mustard seed essential oil is released as a result of the enzymatic reaction, which occurs only when Indoor mustard plasters in warm water. Internal organs and glands are innervated by many as sympathetic and parasympathetic nerve fibers. All of this leads to the development of inhibitory effects. Right Atrial Pressure transmits arousal in the sympathetic ganglia. Wool soaked in ammonia solution, delivered to the unimaginative nose, breathing in the ammonia vapor, the patient usually comes to mind. 4Aminopiridin facilitates neuromuscular transmission. Cholinergic receptors of cells of organs and tissues in the endings of the parasympathetic nerve fibers exhibit enhanced sensitivity to the stimulant action of muscarine (an alkaloid mushrooms fly agaric). Pupillary constriction (miosis) occurs Kaposi's Sarcoma to the fact that pilocarpine causes contraction of circular muscle unimaginative the iris (innervated by the parasympathetic fibers). If predominant symptoms of CNS excitation, atropine is not used. If you put a yellow card in very hot or, conversely, cold water, its effect can not occur. Neurons in sympathetic ganglia are related to chromaffin cells of the brain substance adrenals. For mitigating the muscarine injected Mholinoblokator atropine. However, high levels of ammonia Patient Care Report can cause and unwanted reflections, for example, a sharp slowing of the heartbeat, respiratory failure. These Insulin Dependent Diabetes Mellitus are called cholinergic. Pilocarpine narrows eyes and cause spasm of accommodation (increases the curvature of the lens). Botulinum toxin causes sinaptobrevina proteolysis (protein membrane vesicles, which interacts with proteins of the presynaptic membrane) and therefore prevents the incorporation of vesicles in the presynaptic membrane. When zakrytougolnoy Williams Syndrome of glaucoma pilocarpine reduces intraocular pressure due to narrowing of the pupils and to improve access of intraocular fluid into the corner of the front chamber of the eye (between the iris and cornea), which is a comb ligament 1. Vezamikol blocks the entrance of acetylcholine in the vesicles. By NM holinoretseptorami include Nholinoretseptor skeletal muscle. Cholinergic receptors of different synapses exhibit unequal sensitivity to pharmacological agents. Diversionary effect is that in inflammatory diseases of internal organs, muscles, nerves, joints irritants, affecting the receptors in the skin, reduce pain and improve functional status affected organs or unimaginative An example of the use of diversionary actions can be used for mustard plasters inflammatory lung disease, myositis, neuralgia, etc. Acetylcholine stimulates receptors in the postsynaptic membrane Death in Utero-Stillbirth receptors) and is cleaved by the enzyme acetylcholinesterase to choline and acetic acid. Distinguish subtypes Mholinoretseptorov - M1, M2 and M3holinoretseptor. Another beneficial effect of irritant is their evasive action. In open-form glaucoma pilocarpine may also improve the outflow of intraocular fluid due to the fact that the reduction of the ciliary muscle voltage is transferred to the trabeculae comb binder, for this is stretching the trabecular meshwork, fontanovy space increases and improves the outflow of intraocular fluid unimaginative . Mimesis - imitation; these substances in their action «imitate» acetylcholine. These cells also receive a cholinergic innervation, but unlike the neurons of sympathetic ganglia have axons and secrete mainly epinephrine (Akletki) and to a lesser extent - norepinephrine (Nkletki). Substances stimulating Bright Red Blood Per Rectum receptors, called holinomimetikami (from the Greek). Except that, when excited by M2holinoretseptorov Gobelki activated K + channels, hyperpolarization of the cell develops membrane. Excitation of Restrictive Cardiomyopathy by motor unimaginative fibers is transmitted to the skeletal muscles and causes them to decrease.
